Simian virus 40 small-t antigen binds two zinc ions.

  title={Simian virus 40 small-t antigen binds two zinc ions.},
  author={Brian S. Turk and Anal{\'i}a I. Porr{\'a}s and Marc C. Mumby and Kathleen Rundell},
  journal={Journal of virology},
  volume={67 6},
Six cysteine residues of the simian virus 40 small-t antigen (small-t) are important for stability of the protein. Stability has been shown to be related to the ability of small-t to bind zinc ions in vitro. Purified small-t expressed either in bacteria or from baculovirus vectors binds two molecules of zinc per molecule of protein. Thus, small-t may resemble GAL4, which contains a Zn(II)2Cys6 binuclear cluster. 

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