Simian virus 40 regulatory region structural diversity and the association of viral archetypal regulatory regions with human brain tumors.

@article{Lednicky2001SimianV4,
  title={Simian virus 40 regulatory region structural diversity and the association of viral archetypal regulatory regions with human brain tumors.},
  author={John A Lednicky and Janet S Butel},
  journal={Seminars in cancer biology},
  year={2001},
  volume={11 1},
  pages={
          39-47
        }
}
The regulatory region (RR) of simian virus 40 (SV40) contains enhancer/promoter elements and an origin of DNA replication. Natural SV40 isolates from simian brain or kidney tissues typically have an archetypal RR arrangement with a single 72-basepair enhancer element. A rare simpler, shorter SV40 RR exists that lacks a duplicated sequence in the G/C-rich region and is termed protoarchetypal. Occasionally, SV40 strain variants arise de novo that have complex RRs, which typically contain sequence… CONTINUE READING

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Simian virus 40 in humans

  • Infectious Agents and Cancer
  • 2006
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