Simian virus 40 maturation in cells harboring mutants deleted in the agnogene.

@article{Ng1985SimianV4,
  title={Simian virus 40 maturation in cells harboring mutants deleted in the agnogene.},
  author={Shi Chung Ng and Janet E Mertz and S Sanden-Will and Minou Bina},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 2},
  pages={1127-32}
}
The predominant leader region of the late 16 S mRNAs of simian virus 40 encodes a histone-like, 61-amino acid, DNA-binding protein called the agnoprotein or LP1. To test the hypothesis that this protein facilitates assembly of viral minichromosomes into virions, we have studied the synthesis of virions in cells infected with mutants deleted in this region of the SV40 genome. We found that 220 S mature virions, indistinguishable from those of wild type, were produced in cells infected with these… CONTINUE READING

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