Simian virus 40 large tumor antigen modulates the Raf signaling pathway.

  title={Simian virus 40 large tumor antigen modulates the Raf signaling pathway.},
  author={Nicolas Grammatikakis and Katarzyna Jaronczyk and Aliki Siganou and Adina Vultur and Heather L Brownell and M Benzaquen and Christian Rausch and R{\'e}jean Lapointe and Ole Gjoerup and Thomas M Roberts and Lampros Raptis},
  journal={The Journal of biological chemistry},
  volume={276 30},
The large tumor antigen of simian virus 40 (SVLT) is a potent oncogene. Although inactivation of the p53 and pRb tumor suppressors has been causally linked to the transforming properties of SVLT, its exact mechanism of action remains undefined. Previous data indicated that Ras is activated in SVLT-expressing cells. In this report we show that SVLT also increases Raf kinase activity in both insect and mammalian cells, thus identifying the Raf kinase as an additional target of SVLT. Our results… CONTINUE READING

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