Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products.

@article{Yaciuk1991SimianV4,
  title={Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products.},
  author={Peter Yaciuk and Malcolm C Carter and James M. Pipas and Erica Mor{\'a}n},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 4},
  pages={2116-24}
}
In this report we present evidence that simian virus 40 T antigen encodes a biological activity that is functionally equivalent to the transforming activity lost by deletion of the E1A p300-binding region. T-antigen constructs from which the pRb-binding region has been deleted are virtually unable to induce foci of transformed cells in a ras cooperation assay in primary baby rat kidney cells. Nevertheless, such a construct can cooperate with an E1A N-terminal deletion mutant, itself devoid of… CONTINUE READING