Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.

@article{Hein2009SimianV4,
  title={Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.},
  author={Jennifer Hein and Sergei Boichuk and Jiaping Wu and Yuan Cheng and Raimundo Freire and Parmjit S Jat and Thomas M Roberts and Ole V. Gjoerup},
  journal={Journal of virology},
  year={2009},
  volume={83 1},
  pages={117-27}
}
Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that is important for viral replication and oncogenic transformation. Previously, infection of monkey or human cells with SV40 was shown to lead to the induction of DNA damage response signaling, which is required for efficient viral replication. However, it was not clear if LT is sufficient to induce the damage response and, if so, what the genetic requirements and functional consequences might be. Here, we show that the… CONTINUE READING