Simian virus 40 infection via MHC class I molecules and caveolae.

@article{Norkin1999SimianV4,
  title={Simian virus 40 infection via MHC class I molecules and caveolae.},
  author={Leonard C. Norkin},
  journal={Immunological reviews},
  year={1999},
  volume={168},
  pages={13-22}
}
MHC class I molecules are a necessary component of the cell surface receptor for simian virus 40 (SV40). After binding to class I molecules, SV40 enters cells via a unique endocytic pathway that involves caveolae, rather than clathrin-coated pits. This pathway is dependent on a transmembrane signal that SV40 transmits from the cell surface. Furthermore, it delivers SV40 to the endoplasmic reticulum, rather than to the endosomal/lysosomal compartment, which is the usual target for endocytic… CONTINUE READING