Simian virus 40 T-antigen-mediated gene regulation in enterocytes is controlled primarily by the Rb-E2F pathway.

@article{Rathi2009SimianV4,
  title={Simian virus 40 T-antigen-mediated gene regulation in enterocytes is controlled primarily by the Rb-E2F pathway.},
  author={Abhilasha V Rathi and Maria Teresa S{\'a}enz Robles and Paul G. Cantalupo and Robert H. Whitehead and James M. Pipas},
  journal={Journal of virology},
  year={2009},
  volume={83 18},
  pages={9521-31}
}
Simian virus 40 large T antigen (TAg) contributes to cell transformation, in part, by targeting two well-characterized tumor suppressors, pRb and p53. TAg expression affects the transcriptional circuits controlled by Rb and by p53. We have performed a microarray analysis to examine the global change in gene expression induced by wild-type TAg (TAg(wt)) and TAg mutants, in an effort to link changes in gene expression to specific transforming functions. For this analysis we have used enterocytes… CONTINUE READING