Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.

@article{Doolittle1983SimianSV,
  title={Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.},
  author={Russell F. Doolittle and Michael W. Hunkapiller and Leroy E. Hood and Sushilkumar G. Devare and Keith C. Robbins and Stuart A. Aaronson and Harry N. Antoniades},
  journal={Science},
  year={1983},
  volume={221 4607},
  pages={275-7}
}
The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical… CONTINUE READING
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