Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine.

@article{Nixon2000SimianIV,
  title={Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine.},
  author={Douglas F Nixon and Sean M. Donahoe and William Kakimoto and Rachel V Samuel and Karin J. Metzner and Agegnehu Gettie and Tom{\'a}{\vs} Hanke and Preston A Marx and Ruth I. Connor},
  journal={Virology},
  year={2000},
  volume={266 1},
  pages={203-10}
}
In this study, we examined the role of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes (CTLs) in macaques immunized with an attenuated strain of simian immunodeficiency virus (SIVmac239Deltanef) in protection against pathogenic challenge with SIVmac251. Our results indicate that attenuated SIVmac239Deltanef can elicit specific CTL… CONTINUE READING