Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent.

@article{Joag1995SimianIV,
  title={Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent.},
  author={Shriya Joag and Edward B. Stephens and D Galbreath and Gemma Zhu and Zhuang Ma Li and Larry L Foresman and Ling Zhao and David M. Pinson and Opendra Narayan},
  journal={Journal of virology},
  year={1995},
  volume={69 2},
  pages={1367-9}
}
We inoculated four rhesus macaques with molecularly cloned simian immunodeficiency virus SIVmac239/17E env, a chimeric virus whose env gene was derived from the brain of an SIV-encephalitic macaque. Blood and lymphoid tissues had high frequencies of infected cells. The virus was neuroinvasive, but productive virus replication did not occur in the brain, and animals did not develop encephalitis. 
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