Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.

@article{Zahn2008SimianIV,
  title={Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.},
  author={Roland C. Zahn and Melisa D. Rett and Birgit Korioth-Schmitz and Yue Sun and Adam P. Buzby and Simoy L. Goldstein and Charles R Brown and Russell A. Byrum and Gordon J Freeman and Norman L. Letvin and Vanessa M Hirsch and Joern E Schmitz},
  journal={Journal of virology},
  year={2008},
  volume={82 23},
  pages={11577-88}
}
African green monkeys (AGM) do not develop overt signs of disease following simian immunodeficiency virus (SIV) infection. While it is still unknown how natural hosts like AGM can cope with this lentivirus infection, a large number of investigations have shown that CD8(+) T-cell responses are critical for the containment of AIDS viruses in humans and Asian nonhuman primates. Here we have compared the phenotypes of T-cell subsets and magnitudes of SIV-specific CD8(+) T-cell responses in vervet… CONTINUE READING
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