Simian immunodeficiency virus (SIV) gag DNA-vaccinated rhesus monkeys develop secondary cytotoxic T-lymphocyte responses and control viral replication after pathogenic SIV infection.

@article{Egan2000SimianIV,
  title={Simian immunodeficiency virus (SIV) gag DNA-vaccinated rhesus monkeys develop secondary cytotoxic T-lymphocyte responses and control viral replication after pathogenic SIV infection.},
  author={Michael A. Egan and William A. Charini and Marcelo J. Kuroda and Joern E Schmitz and Paul Racz and Klara Tenner-Racz and Kelledy H. Manson and Michael H Wyand and Michelle A. Lifton and Christine E. Nickerson and Tong-Ming Fu and John Shiver and Norman L. Letvin},
  journal={Journal of virology},
  year={2000},
  volume={74 16},
  pages={7485-95}
}
The potential contribution of a plasmid DNA construct to vaccine-elicited protective immunity was explored in the simian immunodeficiency virus (SIV)/macaque model of AIDS. Making use of soluble major histocompatibility class I/peptide tetramers and peptide-specific killing assays to monitor CD8(+) T-lymphocyte responses to a dominant SIV Gag epitope in genetically selected rhesus monkeys, a codon-optimized SIV gag DNA vaccine construct was shown to elicit a high-frequency SIV-specific… CONTINUE READING