Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.

@article{Peyerl2003SimianhumanIV,
  title={Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.},
  author={Fred W. Peyerl and Dan H Barouch and Wendy W. Yeh and Heidi S. Bazick and Jennifer Kunstman and Kevin J. Kunstman and Steven M. Wolinsky and Norman L. Letvin},
  journal={Journal of virology},
  year={2003},
  volume={77 23},
  pages={12572-8}
}
Virus-specific cytotoxic T lymphocytes (CTL) exert intense selection pressure on replicating simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) in infected individuals. The immunodominant Mamu-A(*)01-restricted Gag p11C, C-M epitope is highly conserved among all sequenced isolates of SIV and therefore likely is structurally constrained. The strategies used by virus isolates to mutate away from an immunodominant epitope-specific CTL response are not well defined… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…