Simian Retrovirus 4 Induces Lethal Acute Thrombocytopenia in Japanese Macaques

@article{Yoshikawa2015SimianR4,
  title={Simian Retrovirus 4 Induces Lethal Acute Thrombocytopenia in Japanese Macaques},
  author={Rokusuke Yoshikawa and Munehiro Okamoto and Shoichi Sakaguchi and So Nakagawa and Tomoyuki Miura and Hirohisa Hirai and Takayuki Miyazawa},
  journal={Journal of Virology},
  year={2015},
  volume={89},
  pages={3965 - 3975}
}
ABSTRACT In 2001-2002, six of seven Japanese macaques (Macaca fuscata) died after developing hemorrhagic syndrome at the Kyoto University Primate Research Institute (KUPRI). While the cause of death was unknown at the time, we detected simian retrovirus 4 (SRV-4) in samples obtained from a similar outbreak in 2008-2011, during which 42 of 43 Japanese macaques died after exhibiting hemorrhagic syndrome. In this study, we isolated SRV-4 strain PRI-172 from a Japanese macaque showing severe… Expand
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