Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae).

@article{Bertani2006SimalikalactoneDI,
  title={Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae).},
  author={S. Bertani and E. Hou{\"e}l and D. Stien and L. Chevolot and V. Jullian and G. Garavito and G. Bourdy and E. Deharo},
  journal={Journal of ethnopharmacology},
  year={2006},
  volume={108 1},
  pages={
          155-7
        }
}
French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC(50) value of 10nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
A new antimalarial quassinoid from Simaba guianensis.
Antiviral activity of simalikalactone D, a quassinoid from Quassia africana.
Phytochemical Potential of Tropical Plants
A new antimalarial quassinoid from Simaba orinocensis.
Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia.
...
1
2
...