Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

@article{Manna1999SilymarinST,
  title={Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.},
  author={Sunil K Manna and Asok Mukhopadhyay and Nguyen Thi Thu Van and Bharat Bhushan Aggarwal},
  journal={Journal of immunology},
  year={1999},
  volume={163 12},
  pages={6800-9}
}
Silymarin is a polyphenolic flavonoid derived from milk thistle (Silybum marianum) that has anti-inflammatory, cytoprotective, and anticarcinogenic effects. How silymarin produces these effects is not understood, but it may involve suppression of NF-kappa B, a nuclear transcription factor, which regulates the expression of various genes involved in inflammation, cytoprotection, and carcinogenesis. In this report, we investigated the effect of silymarin on NF-kappa B activation induced by… CONTINUE READING
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