Silymarin-solid dispersions: characterization and influence of preparation methods on dissolution.

  title={Silymarin-solid dispersions: characterization and influence of preparation methods on dissolution.},
  author={Dalwadi Sonali and Soni Tejal and Thakkar Vaishali and Gandhi Tejal},
  journal={Acta pharmaceutica},
  volume={60 4},
The influence of preparation methodology of silymarin solid dispersions using a hydrophilic polymer on the dissolution performance of silymarin was investigated. Silymarin solid dispersions were prepared using HPMC E 15LV by kneading, spray drying and co-precipitation methods and characterized by FTIR, DSC, XRPD and SEM. Dissolution profiles were compared by statistical and model independent methods. The FTIR and DSC studies revealed weak hydrogen bond formation between the drug and polymer… CONTINUE READING


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