Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study.

@article{Kiruthiga2010SilymarinPP,
  title={Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study.},
  author={Perumal Vijayaraman Kiruthiga and Shunmugiah Karutha Pandian and Kasi Pandima Devi},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={247 2},
  pages={116-28}
}
PAHs are a ubiquitous class of environmental contaminants that have a large number of hazardous consequences on human health. An important prototype of PAHs, B(a)P, is notable for being the first chemical carcinogen to be discovered and the one classified by EPA as a probable human carcinogen. It undergoes metabolic activation to QD, which generate ROS by redox cycling system in the body and oxidatively damage the macromolecules. Hence, a variety of antioxidants have been tested as possible… CONTINUE READING

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