Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats.

@article{Mansour2006SilymarinMC,
  title={Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats.},
  author={Heba Hosny Mansour and Hafez Farouk Hafez and Nadia Mohamed Fahmy},
  journal={Journal of biochemistry and molecular biology},
  year={2006},
  volume={39 6},
  pages={656-61}
}
Cisplatin (CDDP) is a widely used anticancer drug, but at high dose, it can produce undesirable side effects such as hepatotoxicity. Because silymrin has been used to treat liver disorders, the protective effect of silymarin on CDDP-induced hepatotoxicity was evaluated in rats. Hepatotoxicity was determined by changes in serum alanine aminotransferase [ALT… CONTINUE READING