Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers.

@article{Onaolapo2017SilymarinAA,
  title={Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers.},
  author={A Y Onaolapo and Saratu Zayid Abdusalam and Olakunle James Onaolapo},
  journal={Pathophysiology : the official journal of the International Society for Pathophysiology},
  year={2017},
  volume={24 2},
  pages={
          51-62
        }
}
  • A Y Onaolapo, Saratu Zayid Abdusalam, Olakunle James Onaolapo
  • Published 2017
  • Medicine
  • Pathophysiology : the official journal of the International Society for Pathophysiology
  • OBJECTIVE We assessed the impacts of silymarin co-administration on aspartame-induced changes in novelty-induced behaviours, memory, anxiety-related behaviours, cerebral antioxidant status and histomorphology in mice. METHOD Six groups of mice were administered vehicle (distilled water), silymarin (25mg/kg), aspartame (at 160 or 320mg/kg), and silymarin (25mg/kg) co-administered with aspartame at 160 or 320mg/kg daily for 21days, via an oral cannula. Behaviours were assessed after the first… CONTINUE READING

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