Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review

@article{Mastron2015SilymarinAH,
  title={Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review},
  author={Jeanetta K Mastron and Kodappully Sivaraman Siveen and Gautam Sethi and Anupam Bishayee},
  journal={Anti-Cancer Drugs},
  year={2015},
  volume={26},
  pages={475–486}
}
The blessed milk thistle (Silybum marianum L.), a flowering plant native to Mediterranean Europe, has been consumed and extensively used as a cure for various chronic liver ailments over several centuries. Milk thistle extract, known as silymarin, is a complex mixture of seven major flavonolignans and one flavonoid. The phytoconstituents of silymarin owe their therapeutic and hepatoprotective effects to their strong antioxidant and anti-inflammatory properties. Primary liver cancer, also known… 
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Phytomedicine Silybum marianum (Silymarin) as an Effective Hepato-protective source from nature
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Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
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Recent advances in the analysis of flavonolignans of Silybum marianum.
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Clinically, silymarin exerts its hepatoprotective effects through antioxidative, antifibrotic, anti-inflammatory, antitoxin, and anticancerous mechanisms of actions.
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Silymarin and its derivatives play a double role, namely, limiting the progression of cancer cells through different phases of the cycle and accumulating cancer cells in a phase of the cell cycle—thus making it possible to target a greater number of tumor cells with a specific anticancer agent.
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
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The effect of Tanshinones on different cancers, challenges in their pharmacological development, and opportunities to harness their clinical potential have been documented.
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