Silyl-substituted spirodiepoxides: stereoselective formation and regioselective opening.

Abstract

A short synthesis of the natural product epi-citreodiol and the method developed to gain access to this target are described. Key advances focus on silyl substituted allenes. Upon exposure to dimethyldioxirane, spirodiepoxides form with high face selectivity and subsequently react at the silyl terminus. 
DOI: 10.1021/ol901948d

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Cite this paper

@article{Ghosh2009SilylsubstitutedSS, title={Silyl-substituted spirodiepoxides: stereoselective formation and regioselective opening.}, author={Partha Sekhar Ghosh and Joseph R Cusick and Jennifer A Inghrim and Lawrence J. Williams}, journal={Organic letters}, year={2009}, volume={11 20}, pages={4672-5} }