Silybin and its bioavailable phospholipid complex (IdB 1016) potentiate in vitro and in vivo the activity of cisplatin.

@article{Giacomelli2002SilybinAI,
  title={Silybin and its bioavailable phospholipid complex (IdB 1016) potentiate in vitro and in vivo the activity of cisplatin.},
  author={Sabrina Giacomelli and Daniela Gallo and Patrizia Apollonio and Cristiano Ferlini and Mariagrazia Distefano and Paolo Morazzoni and Antonella Riva and Ezio Bombardelli and Salvatore Mancuso and Giovanni Scambia},
  journal={Life sciences},
  year={2002},
  volume={70 12},
  pages={
          1447-59
        }
}
In this study we investigated whether the flavonoid silybin and its bioavailable derivative IdB 1016 (silipide) could enhance the antitumour activity of cisplatin (CDDP), the most commonly used drug in the treatment of gynaecological malignancies. Silybin alone up to 10 (M was unable to produce a relevant in vitro growth inhibition of A2780 cells, whereas CDDP was effective, giving an IC50 value of 0.5+/-0.14 microM. When silybin was combined with CDDP, a dose-dependent and statistically… CONTINUE READING