Silver-staining specificity in metaphases after incorporation of 5-bromodeoxyuridine (BUDR)

  title={Silver-staining specificity in metaphases after incorporation of 5-bromodeoxyuridine (BUDR)},
  author={Walther Vogel and Werner Schempp and V. Puel},
  journal={Human Genetics},
Silver staining is reported to be reduced in chromatin substituted by BUDR. This quenching effect allows for the demonstration of replication patterns and differential chromatid staining. Though the differentiation, as compared to other staining techniques, is of inferior quality, it is of theoretical importance concerning the effect of BUDR incorporation into chromatin. 

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