Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity.

@article{Samberg2012SilverND,
  title={Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity.},
  author={Meghan E. Samberg and Elizabeth G. Loboa and Steven J. Oldenburg and Nancy A Monteiro-Riviere},
  journal={Nanomedicine},
  year={2012},
  volume={7 8},
  pages={1197-209}
}
AIMS To evaluate the toxicity and cellular uptake of both undifferentiated and differentiated human adipose-derived stem cells (hASCs) exposed to silver nanoparticles (Ag-NPs), and to assess their effect on hASC differentiation. MATERIALS & METHODS hASC were exposed to 10- or 20-nm Ag-NPs at concentrations of 0.1, 1.0, 10.0, 50.0 and 100.0 µg/ml either before or after differentiation down the adipogenic or osteogenic pathways. RESULTS Exposure of hASC to either 10- or 20-nm Ag-NPs resulted… CONTINUE READING

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