Silver-coated megaendoprostheses in a rabbit model--an analysis of the infection rate and toxicological side effects.

@article{Gosheger2004SilvercoatedMI,
  title={Silver-coated megaendoprostheses in a rabbit model--an analysis of the infection rate and toxicological side effects.},
  author={Georg Gosheger and Jendrik Hardes and Helmut Ahrens and Arne Streitburger and Horst Buerger and Michael Erren and Andreas Gunsel and Fritz H Kemper and Winfried Winkelmann and Christof von Eiff},
  journal={Biomaterials},
  year={2004},
  volume={25 24},
  pages={5547-56}
}
Deep infection of megaprostheses remains a serious complication in orthopedic tumor surgery. Despite the use of systemic and local antibiotic prophylaxis the reported infection rate is between 5% and 35%. Silver-coated medical devices proved their effectiveness in reducing infections. The objective of this study was to examine in vivo the antimicrobial efficacy and possible side-effects of a silver-coated megaprosthesis. In a first study, 30 rabbits (15 titanium versus 15 silver-coated Mutars… CONTINUE READING

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