Silver-catalyzed intramolecular cyclization of 9-propargyladenine via N3 alkylation.

@article{Prajapati2010SilvercatalyzedIC,
  title={Silver-catalyzed intramolecular cyclization of 9-propargyladenine via N3 alkylation.},
  author={Rajneesh Kumar Prajapati and Jitendra Kumar and Sandeep Verma},
  journal={Chemical communications},
  year={2010},
  volume={46 19},
  pages={
          3312-4
        }
}
We report the formation of a highly unusual fused, tricyclic purine derivative via N3 alkylation of 9-propargyladenine, upon activation of the acetylenic triple bond by Ag(I) ions. The participation of silver ions in this process might offer newer design paradigms for minor groove N3 DNA alkylation, antibacterial and anticancer agents. 
18 Citations
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