Silver activates mast cells through reactive oxygen species production and a thiol-sensitive store-independent Ca2+ influx.

@article{Yoshimaru2006SilverAM,
  title={Silver activates mast cells through reactive oxygen species production and a thiol-sensitive store-independent Ca2+ influx.},
  author={Tetsuro Yoshimaru and Yoshihiro Suzuki and Toshio Inoue and Osamu Niide and Chisei Ra},
  journal={Free radical biology & medicine},
  year={2006},
  volume={40 11},
  pages={1949-59}
}
In genetically susceptible human and/or experimental animals, heavy metals such as mercury, gold, and silver have been shown to highly induce adverse immunological reactions such as allergy and autoimmunity, in which mast cell degranulation is implicated as playing a role. We previously reported that silver activates mast cells and induces Ca2+ influx without stimulating intracellular signaling events required for activation of store-operated Ca2+ channels (SOCs). The purpose of the present… CONTINUE READING