Silver-Mediated Radical C(sp3)-H Biphosphinylation and Nitration of β-Alkynyl Ketones for Accessing Functional Isochromenes.

Abstract

Silver-mediated C(sp3)-H functionalization and 6-endo-dig oxo-cyclization of conjugated β-alkynyl ketones have been established under oxidative conditions. The reaction leads to the concise formation of a wide range of isochromenes via C(sp3)-H bond-breaking and radical addition steps. Dual and monofunctional isochromene products were selectively controlled by using either electron-rich or electron-deficient radical sources.

DOI: 10.1021/acs.orglett.6b03546

Cite this paper

@article{Sun2017SilverMediatedRC, title={Silver-Mediated Radical C(sp3)-H Biphosphinylation and Nitration of β-Alkynyl Ketones for Accessing Functional Isochromenes.}, author={Jun Sun and Jiang-Kai Qiu and Ya-Nan Wu and Wen-Juan Hao and Cheng Guo and Guigen Li and Shujiang Tu and Bo Jiang}, journal={Organic letters}, year={2017}, volume={19 4}, pages={754-757} }