Silver(I)- or copper(II)-mediated dearomatization of aromatic ynones: direct access to spirocyclic scaffolds.

Abstract

A high-yielding silver(I)- or copper(II)-catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain ynone substituents, including indole, anisole, pyrrole, and benzofuran derivatives, into functionalized spirocyclic scaffolds. A high-yielding asymmetric variant furnishes spirocyclic indolenines in up to 89:11 e.r.

DOI: 10.1002/anie.201501812

Cite this paper

@article{James2015SilverIOC, title={Silver(I)- or copper(II)-mediated dearomatization of aromatic ynones: direct access to spirocyclic scaffolds.}, author={Michael John James and James D Cuthbertson and Peter R. O'Brien and Richard J. Taylor and William P Unsworth}, journal={Angewandte Chemie}, year={2015}, volume={54 26}, pages={7640-3} }