Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids.

  title={Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids.},
  author={Xinqiang Tan and Zhonglin Liu and Haigen Shen and Pei Zhang and Zhenzhen Zhang and Chaozhong Li},
  journal={Journal of the American Chemical Society},
  volume={139 36},
The silver-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids is described. With AgNO3 as the catalyst and K2S2O8 as the oxidant, the reactions of aliphatic carboxylic acids with (bpy)Cu(CF3)3 (bpy = 2,2'-bipyridine) and ZnMe2 in aqueous acetonitrile at 40 °C afford the corresponding decarboxylative trifluoromethylation products in good yield. The protocol is applicable to various primary and secondary alkyl carboxylic acids and exhibits wide functional group… CONTINUE READING

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