Silver-Catalyzed, Aldehyde-Induced α-C-H Functionalization of Tetrahydroisoquinolines with Concurrent C-P Bond Formation/N-Alkylation.

@article{Hu2016SilverCatalyzedA,
  title={Silver-Catalyzed, Aldehyde-Induced α-C-H Functionalization of Tetrahydroisoquinolines with Concurrent C-P Bond Formation/N-Alkylation.},
  author={Gaobo Hu and Weizhu Chen and Dumei Ma and Yun Fei Zhang and Pengxiang Xu and Yuxing Gao and Yufen Zhao},
  journal={The Journal of organic chemistry},
  year={2016},
  volume={81 4},
  pages={1704-11}
}
The first facile and efficient silver-catalyzed, aldehyde-induced three-component reaction of N-unprotected tetrahydroisoquinolines, aldehydes, and dialkyl phosphonates has been developed, providing a general one-step approach to structurally diverse C1-phosphonylated THIQs accompanied by concurrent C-P bond formation/N-alkylation with remarkable functional group tolerance and excellent regioselectivity for endo products. 

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