Silver‐coated endotracheal tube versus non‐coated endotracheal tube for preventing ventilator‐associated pneumonia among adults: A systematic review of randomized controlled trials

  title={Silver‐coated endotracheal tube versus non‐coated endotracheal tube for preventing ventilator‐associated pneumonia among adults: A systematic review of randomized controlled trials},
  author={Xiao Li and Qiang Yuan and Li Wang and Liang Du and Lijing Deng},
  journal={Journal of Evidence‐Based Medicine},
Objective: To compare the effects of using silver‐coated endotracheal tube (ETT) versus non‐coated ETT on the incidence of ventilator‐associated pneumonia (VAP) and mortality in adult patients. 
Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients.
Silver-coated ETTs were associated with delayed time to VAP occurrence and there was a high risk of detection bias owing to lack of blinding of outcomes assessors, but all other domains were assessed to be at low risk of bias.
The Effect Of Silver-Coated Endotracheal Tube On The Incidence Of Ventilator-Induced Pneumonia In Intubated Patients Admitted To The Intensive Care Unit (ICU)
Silver-coated endotracheal tube has a more effective role in improving the prognosis of intubated patients admitted to the ICU when comparing with standard non-coating endotrachal tube.
Endotracheal Tubes: Old and New
Modifications to the endotracheal tube that attempt to prevent bacteria from entering around the ETT include maintaining an adequate cuff pressure against the tracheal wall, changing the material and shape of the cuff, and aspirating the secretions that sit above the cuff.
An endotracheal tube providing “pressurized sealing” prevents fluid leakage in mechanically ventilated critically ill patients: a pilot study
A prototype double-cuffed ETT equipped with a supplemental port in-between the cuffs, offering “pressurized sealing” of the trachea, safely and effectively prevented leakage during 24 h mechanical ventilation.
Prevention of ventilator-associated pneumonia.
It is suggested that all units treating mechanically ventilated patients should have a ventilator-associated pneumonia prevention protocol in place, and ventilators should be seriously considered as a key performance indicator in local intensive care units.
The management of periprosthetic infections in the future: a review of new forms of treatment.
The challenge to prevent and eradicate periprosthetic joint infections has resulted in the emergence of several new strategies, which are discussed in this review.
Implantable Medical Devices Treated with Antimicrobial Agents
Current products in use in the healthcare field as well as some promising active agents that are in the beginning or advanced stages of market approval and release are discussed.
The silver cation (Ag+): antibacterial mode of action and mechanisms of resistance
Detailed characterisation of a known Ag+-resistance determinant was conducted to provide further insights into the mechanism of Ag+ resistance conferred by this determinant, which could potentially be applied to optimising the future uses of Ag+, as an antibacterial agent.
Antimicrobial Effect of Silver Nanoparticles on Staphylococcus Aureus
The results of this experiment suggest that biologically synthesized silver nanoparticles are fairly ideal candidates for development of new antimicrobial drugs against S. aureus.


Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial.
Patients receiving a silver-coated endotracheal tube had a statistically significant reduction in the incidence of VAP and delayed time to VAP occurrence compared with those receiving a similar, uncoated tube.
Association between a silver-coated endotracheal tube and reduced mortality in patients with ventilator-associated pneumonia.
It is suggested that a silver-coated ETT was associated with reduced mortality in patients who developed VAP in the NASCENT study, and inappropriate antibiotics remained in the model.
Silver-coated endotracheal tubes associated with reduced bacterial burden in the lungs of mechanically ventilated dogs.
It is suggested that the silver coating of endotracheal tubes may delay the onset of and decrease the severity of lung colonization by aerobic bacteria.
Cost-Effectiveness Analysis of a Silver-Coated Endotracheal Tube to Reduce the Incidence of Ventilator-Associated Pneumonia
The silver-coated endotracheal tube represents a strategy for preventing VAP that may yield hospital savings and, in multivariate sensitivity analyses, yielded persistent savings per case of VAP prevented.
Reduced burden of bacterial airway colonization with a novel silver-coated endotracheal tube in a randomized multiple-center feasibility study*
In this prospectively planned, preliminary analysis, the RIC device was feasible and well tolerated and larger studies are needed to determine whether delayed colonization, reduced colonization rate, and decreased bacterial burden will decrease the incidence of ventilator-associated pneumonia.
Endotracheal Tubes Coated with Antiseptics Decrease Bacterial Colonization of the Ventilator Circuits, Lungs, and Endotracheal Tube
Coated ETTs induced a nonsignificant reduction of the tracheal colonization, eliminated or reduced (one of eight) bacterial colonization of the ETT and ventilator circuits, and prevented lung bacterial colonization.
Antimicrobial-coated endotracheal tubes: an experimental study
Several effective and durable antibacterial coatings for ETTs are described, particularly SSD-ETT showed prevention against P. aeruginosa biofilm formation in a 72-h in-vitro study and lower respiratory tract colonization in sheep mechanically ventilated for 24 h.
Implications of endotracheal tube biofilm for ventilator-associated pneumonia
Susceptibility data for these pairs show that the ET acts as a reservoir for infecting microorganisms which exhibit significantly greater antibiotic resistance than their tracheal counterparts.
Nosocomial pulmonary infection: Possible etiologic significance of bacterial adhesion to endotracheal tubes
The mechanism by which endotracheal tubes repeatedly inoculate the lungs of intubated patients may prove to be dislodgment of such aggregates by suction apparatus.