Silver/dendrimer nanocomposites as biomarkers: fabrication, characterization, in vitro toxicity, and intracellular detection.

@article{Leniak2005SilverdendrimerNA,
  title={Silver/dendrimer nanocomposites as biomarkers: fabrication, characterization, in vitro toxicity, and intracellular detection.},
  author={Wojciech Leśniak and Anna U. Bielinska and Kai Sun and Katarzyna W. Janczak and Xiangyang Shi and James R Baker and Lajos P. Balogh},
  journal={Nano letters},
  year={2005},
  volume={5 11},
  pages={2123-30}
}
We have synthesized water-soluble, biocompatible, fluorescent, and stable silver/dendrimer nanocomposites that exhibit a potential for in vitro cell labeling. Amino-, hydroxyl-, and carboxyl-terminated ethylenediamine core generation 5 poly(amidoamine) dendrimers were utilized to prepare aqueous silver(I)-dendrimer complexes (with the molar ratio of 25 Ag+ per dendrimer) at the biologic pH of 7.4. Conversion of silver(I)-dendrimer complexes into dendrimer nanocomposites was achieved by… CONTINUE READING

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