Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties.

@article{Teul2012SilkwormsTW,
  title={Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties.},
  author={Florence Teul{\'e} and Yun-gen Miao and Bong-Hee Sohn and Young-Soo Kim and Jonathan J. Hull and Malcolm J. Fraser and Randolph V Lewis and Donald L. Jarvis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 3},
  pages={923-8}
}
The development of a spider silk-manufacturing process is of great interest. However, there are serious problems with natural manufacturing through spider farming, and standard recombinant protein production platforms have provided limited progress due to their inability to assemble spider silk proteins into fibers. Thus, we used piggyBac vectors to create transgenic silkworms encoding chimeric silkworm/spider silk proteins. The silk fibers produced by these animals were composite materials… CONTINUE READING
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