Silkworm pathogenic bacteria infection model for identification of novel virulence genes.

@article{Kaito2005SilkwormPB,
  title={Silkworm pathogenic bacteria infection model for identification of novel virulence genes.},
  author={Chikara Kaito and Kenji Kurokawa and Yasuhiko Matsumoto and Yutaka Terao and Shigetada Kawabata and Shigeyuki Hamada and Kazuhisa Sekimizu},
  journal={Molecular microbiology},
  year={2005},
  volume={56 4},
  pages={934-44}
}
Silkworms are killed by injection of pathogenic bacteria, such as Staphylococcus aureus and Streptococcus pyogenes, into the haemolymph. Gene disruption mutants of S. aureus whose open reading frames were previously uncharacterized and that are conserved among bacteria were examined for their virulence in silkworms. Of these 100 genes, three genes named cvfA, cvfB, and cvfC were required for full virulence of S. aureus in silkworms. Haemolysin production was decreased in these mutants. The cvfA… CONTINUE READING

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