Silkworm larvae as an animal model of bacterial infection pathogenic to humans.

@article{Kaito2002SilkwormLA,
  title={Silkworm larvae as an animal model of bacterial infection pathogenic to humans.},
  author={Chikara Kaito and Nobuyoshi Akimitsu and Haruo Watanabe and Kazuhisa Sekimizu},
  journal={Microbial pathogenesis},
  year={2002},
  volume={32 4},
  pages={
          183-90
        }
}
Silkworm larvae, Bombyx mori, were examined as an animal model of human infection with pathogenic bacteria. When 3 x 10(7) cells of Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa, or Vibrio cholerae were injected into the blood of fifth instar silkworm larvae, over 90% of the larvae died within 2 days, whereas over 90% survived for 5 days after injection of the same amount of Escherichia coli. Growth of S. aureus was observed in larvae blood and tissues. Immunostaining analysis… CONTINUE READING
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