Silk fibroin hydrolysate inhibits osteoclastogenesis and induces apoptosis of osteoclasts derived from RAW 264.7 cells.

@article{Chon2012SilkFH,
  title={Silk fibroin hydrolysate inhibits osteoclastogenesis and induces apoptosis of osteoclasts derived from RAW 264.7 cells.},
  author={Jeon-Woo Chon and Hyeryeon Kim and Ha-Na Jeon and Kyungho Park and Kwang-gill Lee and Joo-hong Yeo and Haeyong Kweon and Heui-Sam Lee and You-Young Jo and Yoo Kyoung Park},
  journal={International journal of molecular medicine},
  year={2012},
  volume={30 5},
  pages={
          1203-10
        }
}
Bone disease can be associated with bone resorption by osteoclasts, and interest in the development of antiresorptive agents has recently increased. The hydrolysate of silk fibroin has been studied with respect to such biomedical applications. In a previous study, silk fibroin showed indirect inhibitory effects on the differentiation of osteoclasts. To further evaluate the effect of a hydrolysate of silk fibroin on osteoclasts, we investigated the direct effects of the silk fibroin hydrolysate… CONTINUE READING

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