Silicone-Based Scar Therapy: A Review of the Literature

@article{Stavrou2010SiliconeBasedST,
  title={Silicone-Based Scar Therapy: A Review of the Literature},
  author={Demetris Stavrou and Oren Weissman and Eyal Winkler and Lior Yankelson and Eran Millet and Oren Paul Mushin and Alon Liran and Josef Haik},
  journal={Aesthetic Plastic Surgery},
  year={2010},
  volume={34},
  pages={646-651}
}
Hypertrophic and keloid scars still are among the banes of plastic surgery. In the treatment arsenal at the disposal of the plastic surgeon, topical silicone therapy usually is considered the first line of treatment or as an adjuvant to other treatment methods. Yet, knowledge concerning its mechanisms of action, clinical efficacy, and possible adverse effects is rather obscure and sometimes conflicting. This review briefly summarizes the existing literature regarding the silicone elastomer’s… 
Advances in scar management: prevention and management of hypertrophic scars and keloids
TLDR
Although there remains no ‘gold standard’ for the prevention and treatment of hypertrophic scars and keloids, silicone gel products and microporous paper tape present the best conservative options.
Topical Agents for Scar Management: Are They Effective?
  • C. Zoumalan
  • Biology
    Journal of drugs in dermatology : JDD
  • 2018
TLDR
An overview of topical treatments utilized for scar management, including their mechanism of action and evidence of efficacy are provided, and the pathophysiology of wound healing is also reviewed.
Update on Scar Management: Guidelines for Treating Asian Patients
TLDR
Following surgery, scar prevention should be initiated in all Asian patients due to the high risk of poor scars and there is strong evidence for the efficacy of silicone based products, and they can be considered first-line therapy.
Prevention of Postsurgical Scars: Comparsion of Efficacy and Convenience between Silicone Gel Sheet and Topical Silicone Gel
TLDR
The results reveal not only that no significant difference in efficacy exists between the 2 products but also that topical silicone gels are more convenient to use.
Medical Therapy of Burn Scar Before Any Plastic Surgery by Using Topical Corticosteroid Combined with Oral Zinc Sulfate
TLDR
Medical therapeutic intervention should be started as early as possible to minimize scar formation, to reduce the scar size and treat pigmentary problems, this therapeutic trial will minimize plastic surgery need.
The effect of silicone gel versus contractubex gel on the upper-extremity postsurgical scars: A randomized, double-blinded, controlled trial
TLDR
Vascularity, pliability, pigmentation and height, as subjective scar parameters, were not statistically different in post-upper extremity sharp injury wound hypertrophic scar among the groups.
Collagenase Followed by Compression for the Treatment of Earlobe Keloids
TLDR
Intralesional collagenase followed by compression appears to be a safe and modestly effective treatment for earlobe keloids, and warrants further investigation in larger studies with longer follow-up in motivated patients who decline surgical excision.
Safety and Efficacy of a Scar Cream Consisting of Highly Selective Growth Factors Within a Silicone Cream Matrix: A Double-Blinded, Randomized, Multicenter Study
TLDR
SKN2017B consists of highly selective growth factors within a silicone cream matrix and is well tolerated and effective for surgical scar management.
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References

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TLDR
The purpose of this communication is to propose a mechanism not considered before and to include some preliminary laboratory results that are supportive of this proposal, which has implications for the pathogenesis of hypertrophic scars.
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TLDR
The purpose of this article is to review the literature on silicone elastomer sheeting products and to discuss their clinical application in the treatment and prevention of hypertrophic and keloid scars.
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TLDR
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TLDR
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TLDR
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TLDR
The results suggest that patients treated with the soft silicone dressing experienced greater and more rapid improvements compared with non-treated patients, and the fact that Mepiform is self-adhesive and causes limited damage to the stratum corneum on removal gives it an added value compared withNon-adhesion silicone gel dressings.
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TLDR
There is weak evidence of a benefit of silicone gel sheeting as a prevention for abnormal scarring in high-risk individuals but the poor quality of research means a great deal of uncertainty prevails.
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