Silicon-rich mineral water as a non-invasive test of the 'aluminum hypothesis' in Alzheimer's disease.

@article{Davenward2013SiliconrichMW,
  title={Silicon-rich mineral water as a non-invasive test of the 'aluminum hypothesis' in Alzheimer's disease.},
  author={Samantha Davenward and Peter Bentham and Jan Wright and Peter Crome and Deborah Job and Anthony Polwart and Christopher Exley},
  journal={Journal of Alzheimer's disease : JAD},
  year={2013},
  volume={33 2},
  pages={
          423-30
        }
}
There has been a plausible link between human exposure to aluminum and Alzheimer's disease for several decades. [] Key Method Herein we are testing the hypothesis that silicon-rich mineral waters can be used as non-invasive methods to reduce the body burden of aluminum in individuals with Alzheimer's disease and a control group consisting of their carers and partners. We have shown that drinking up to 1 L of a silicon-rich mineral water each day for 12 weeks facilitated the removal of aluminum via the urine…

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References

SHOWING 1-10 OF 20 REFERENCES

Non-invasive therapy to reduce the body burden of aluminium in Alzheimer's disease.

TLDR
The reduction in urinary aluminium supported the future longer-term use of silicic acid as non-invasive therapy for reducing the body burden of aluminium in Alzheimer's disease.

Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?

TLDR
The hypothesis that Al significantly contributes to AD is built upon very solid experimental evidence and should not be dismissed, and immediate steps should be taken to lessen human exposure to Al, which may be the single most aggravating and avoidable factor related to AD.

The neurotoxicity of environmental aluminum is still an issue.

Aluminium, iron and copper in human brain tissues donated to the Medical Research Council's Cognitive Function and Ageing Study.

TLDR
The value of carrying out significant numbers of method blanks to identify unknown sources of contamination is shown and when these values are subtracted from tissue digest values the absolute metal contents could be considered as conservative and yet they may still reflect aspects of ageing and neurodegenerative disease in individual brains.

Effect of silicon on gastrointestinal absorption of aluminium

Intramuscular desferrioxamine in patients with Alzheimer's disease

Aluminium in the human brain

TLDR
A feasible test of the ‘aluminium hypothesis’, whereby aluminium in the human brain is implicated in chronic neurodegenerative disease, would be to reduce the brain’s aluminium load to the lowest possible level by non-invasive means.

Kinetics of uptake and elimination of silicic acid by a human subject: a novel application of 32Si and accelerator mass spectrometry.

Acute toxicity of aluminium to fish eliminated in silicon-rich acid waters

AN increased level of aluminium in acidified natural waters is a primary cause of fish death from damage to gill epithelia and loss of osmoregulatory capacity1–4. Aluminium toxicity depends on the