Silicon nanowires for sequence-specific DNA sensing: device fabrication and simulation

@article{Li2005SiliconNF,
  title={Silicon nanowires for sequence-specific DNA sensing: device fabrication and simulation},
  author={Zhiyong Li and Bipin Rajendran and Theodore I Kamins and Xuema Li and Yongming Chen and R. Stanley Williams},
  journal={Applied Physics A},
  year={2005},
  volume={80},
  pages={1257-1263}
}
Highly sensitive, sequence-specific and label-free DNA sensors were demonstrated by monitoring the electronic conductance of silicon nanowires (SiNWs) with chemically bonded single-stranded (ss) DNA or peptide nucleic acid (PNA) probe molecules. For a 12-mer oligonucleotide, tens of pM of target ss-DNA in solution was recognized when the complementary DNA oligonucleotide probe was attached to the SiNW surfaces. In contrast, ss-DNA samples of ×1000 concentration with a single-base mismatch… CONTINUE READING

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