Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells.

@article{Tan2015SiliconNM,
  title={Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells.},
  author={Yu Yuan Tan and Dylan Jack Richards and Ruoyu Xu and Skylar Stewart-Clark and Santhosh K. Mani and Thomas K Borg and Donald R. Menick and Bozhi Tian and Ying Mei},
  journal={Nano letters},
  year={2015},
  volume={15 5},
  pages={
          2765-72
        }
}
The current inability to derive mature cardiomyocytes from human pluripotent stem cells has been the limiting step for transitioning this powerful technology into clinical therapies. To address this, scaffold-based tissue engineering approaches have been utilized to mimic heart development in vitro and promote maturation of cardiomyocytes derived from human pluripotent stem cells. While scaffolds can provide 3D microenvironments, current scaffolds lack the matched physical/chemical/biological… CONTINUE READING
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