Silicon absorption and excretion is independent of age and sex in adults

@article{Jugdaohsingh2013SiliconAA,
  title={Silicon absorption and excretion is independent of age and sex in adults},
  author={Ravin Jugdaohsingh and Supannee Sripanyakorn and Jonathan J. Powell},
  journal={British Journal of Nutrition},
  year={2013},
  volume={110},
  pages={1024 - 1030}
}
Host factors influencing the absorption and excretion of Si are poorly understood, although previous murine and human studies have suggested that age, sex and oestrogen status may affect Si metabolism and thus function. Here, serum and urine samples were collected from twenty-six healthy adults at baseline and over a 6 h period following ingestion of 17·4 mg Si (orthosilicic acid) and analysed by inductively coupled plasma optical emission spectrometry. Fasting baseline serum and urinary Si… 
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18 Citations
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Results Citations
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18 Citations

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Citation Type

Urinary Excretion of Silicon in Men, Non-pregnant Women, and Pregnant Women: a Cross-sectional Study
TLDR
The higher urinary excretion by pregnant women compared with men and non-pregnant women is a novel finding possibly caused by temporary physiological changes during pregnancy such as increased gastrointestinal uptake of Si, altered bone metabolism, and increased renal excretion of Si.
Relationship Between Dietary Intake and Urinary Excretion of Silicon in Free-Living Korean Adult Men and Women
TLDR
A significantly positive correlation was found in men, but not in women regarding the relationship between dietary Si intake and urinary Si excretion, and longitudinal and balance studies to elucidate gender differences in Si nutrition are needed.
Silicon balance in human volunteers; a pilot study to establish the variance in silicon excretion versus intake
TLDR
In healthy subjects (presumably in Si balance), the ingestion of a soluble dose of dietary Si results in the same quantity being excreted within 24 h, and isotopic studies are now merited.
A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males
TLDR
Blood levels of arginine, silicon, and NO (salivary nitrite) were elevated consistently after 14 days of use and the product was found to be safe, supporting information that there was some improvement in NO production.
The silicon supplement ‘Monomethylsilanetriol’ is safe and increases the body pool of silicon in healthy Pre-menopausal women
TLDR
The data indicate that oral MMST is safe, is absorbed and undergoes sufficient metabolism in vivo to raise fasting serum silicon levels, consistent with other well absorbed forms of dietary silicon (e.g. orthosilicic acid).
A clinical evaluation to determine the safety, pharmacokinetics and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. (LB418)
TLDR
The purpose of this study was to characterize the PK/PD of Nitrosigine™, an inositol-stabilized arginine silicate dietary supplement, and to show trends towards being higher than baseline Day 1.
Simvastatin Effect on Calcium and Silicon Plasma Levels in Postmenopausal Women with Osteoarthritis
TLDR
A statistically significant decrease in the plasma calcium concentration of postmenopausal women, treated with simvastatin suggests that simvastsatin may play a role in calcium metabolism in post menopausal women with osteoarthritis.
Correlations among plasma silicon, magnesium and calcium in patients with knee osteoarthritis - analysis in consideration of gender.
TLDR
Silicon increase in OA patients, especially in men, may indicate its intense metabolism during the articular inflammatory process, likely dependent on sex hormones.
Sub-chronic toxicity study in rats orally exposed to nanostructured silica
TLDR
Although only few adverse effects were observed, additional studies are warranted to further evaluate the biological relevance of observed fibrosis in liver and possible accumulation of silica in the spleen in the NM-202 and SAS exposed animals respectively.
Silicon-containing water intake confers antioxidant effect, gastrointestinal protection, and gut microbiota modulation in the rodents
TLDR
This study pioneerly provided scientific evidences for the potential effects of water-soluble forms of silicon intake on antioxidant activity, gastrointestinal function, and gut microbiota modulation.
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