Silica nanoparticles induce liver fibrosis via TGF-β1/Smad3 pathway in ICR mice

@inproceedings{Yu2017SilicaNI,
  title={Silica nanoparticles induce liver fibrosis via TGF-β1/Smad3 pathway in ICR mice},
  author={Yang Yu and Junchao Duan and Yang Li and Yanbo Li and Li Jing and Man Yang and Ji Wang and Zhiwei Sun},
  booktitle={International journal of nanomedicine},
  year={2017}
}
The liver is one of the target organs of silica nanoparticles (SiO2 NPs) but the toxic mechanism on the liver still remains unclear. This study aimed to explore the hepatic toxicity and its mechanism through repeated intravenous exposure to SiO2 NPs in ICR mice. Results indicated that SiO2 NPs could be distributed in hepatocytes, Kupffer cells, and hepatic stellate cells, and induce hepatic dysfunction as well as granuloma formation in the liver. The increase of lipid peroxide level and… CONTINUE READING
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Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro

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