Silica induces NLRP3 inflammasome activation in human lung epithelial cells

@inproceedings{Peeters2012SilicaIN,
  title={Silica induces NLRP3 inflammasome activation in human lung epithelial cells},
  author={Paul M. J. G. Peeters and Timothy N Perkins and Emiel F. M. Wouters and Brooke T. Mossman and Niki L. Reynaert},
  booktitle={Particle and Fibre Toxicology},
  year={2012}
}
In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we investigated lung epithelial cells as a target for silica-induced inflammasome activation. A human bronchial epithelial cell line (BEAS-2B) and primary normal human bronchial epithelial cells… CONTINUE READING
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