Silica-exposed macrophages release a growth-promoting activity for type II pneumocytes.

@article{Melloni1993SilicaexposedMR,
  title={Silica-exposed macrophages release a growth-promoting activity for type II pneumocytes.},
  author={Boris Melloni and Olivier Lesur and Andr{\'e} M. Cantin and Raymond O. Begin},
  journal={Journal of leukocyte biology},
  year={1993},
  volume={53 3},
  pages={327-35}
}
This study addresses the hypothesis that silica-activated alveolar macrophages could release soluble factors stimulating type II cell proliferation. Macrophages from control sheep were exposed or not in vitro to silica, aluminum-treated silica (Si-Al), or titanium dioxide (TiO2). In addition, macrophages from a model of chromic silica-exposed sheep were studied. Supernatants from unstimulated macrophages were found to double basal type II cell DNA synthesis. Alveolar macrophage-conditioned… CONTINUE READING