Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells

@article{Agarwal2003SilibininUT,
  title={Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells},
  author={C. Agarwal and R. Singh and S. Dhanalakshmi and A. Tyagi and M. Tecklenburg and R. Sclafani and R. Agarwal},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={8271-8282}
}
Silymarin, a defined mixture of natural flavonoid, has recently been shown to have potent cancer chemopreventive efficacy against colon carcinogenesis in rat model; however, the mechanism of such efficacy is not elucidated. Here, using pure active agent in silymarin, namely silibinin, we show its antiproliferative and apoptotic effects, and associated molecular alterations in human colon carcinoma HT-29 cells. Silibinin treatment of cells at 50–100 μg/ml doses resulted in a moderate to very… Expand
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TLDR
It is suggested that silibinin modulates CDKI-CDK-cyclin cascade and activates caspase 3 causing growth inhibition and apoptotic death of human TCC cells, providing a strong rationale for future studies evaluating preventive and/or intervention strategies for silib inin in bladder cancer pre-clinical models. Expand
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TLDR
Together, for the first time, these results identify potential molecular targets and anticancer effects of silibinin in NSCLC cells representing differentNSCLC subtypes. Expand
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TLDR
The data show that silibinin almost completely inhibits growth of human umbilical vein endothelial cells (HUVEC) and human microvascular endothelial Cells (HMVEC-dermal origin) together with induction of cell death in a dose- and time-dependent manner, and identifies pleiotropic mechanisms for antiangiogenic efficacy of silib in endothelial cell culture system. Expand
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TLDR
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TLDR
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TLDR
The results indicated that silibinin effectively inhibits the renal cancer carcinoma Caki-1 cell proliferation and induces apoptosis through inhibiting the activation of EGFR and ERK and the expression of survivin, up-regulating theexpression of p53 and triggering the cascades of caspase pathways. Expand
Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3β release from Cdc25C and Chk2 activation in human bladder transitional carcinoma cells.
TLDR
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Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells.
TLDR
This study found that combination treatment of HDAC inhibitor and silibinin exerted additive growth inhibitory effect on pancreatic cancer cell and might indicate that the novel combination of HDac inhibitor andsilibin in could offer therapeutic potential against pancreaticcancer. Expand
Silibinin Triggers Apoptosis and Cell‐Cycle Arrest of SGC7901 Cells
TLDR
Results indicated that Silibinin is a cell‐cycle regulator and apoptosis inducer in human gastric carcinoma SGC‐7901 cells and might be used as a candidate chemopreventive agent for gastric cancer prevention and intervention. Expand
Silibinin Inhibits Cell Growth and Induces Apoptosis through Cell-cycle Arrest in PC-3 Prostate Cancer Cells
TLDR
It is suggested that apoptosis of prostate cancer cell line PC-3 induced by silibinin is associated with cell cycle arrest through decrease of cell cycle check point proteins, caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage. Expand
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