Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin.

@article{Son2007SilibininSH,
  title={Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin.},
  author={Yong-gyu Son and Eun Hee Kim and Jin Yeop Kim and Seung Up Kim and Taeg Kyu Kwon and A-rum Yoon and Chae-Ok Yun and Kyeong Sook Choi},
  journal={Cancer research},
  year={2007},
  volume={67 17},
  pages={8274-84}
}
Silibinin, a flavonoid isolated from Silybum marianum, has been reported to have cancer chemopreventive and therapeutic effects. Here, we show that treatment with subtoxic doses of silibinin in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis in TRAIL-resistant glioma cells, but not in human astrocytes, suggesting that this combined treatment may offer an attractive strategy for safely treating gliomas. Although the proteolytic processing… CONTINUE READING

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