Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death

@inproceedings{Jeong2011SilibininIA,
  title={Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death},
  author={Ji Cheon Jeong and Won Yong Shin and Thae Hyun Kim and Chae H Kwon and Jae H Kim and Yong Kyun Kim and Ki Hyung Kim},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2011}
}
BackgroundSilibinin, a natural polyphenolic flavonoid, has been reported to induce cell death in various cancer cell types. However, the molecular mechanism is not clearly defined. Our previous study showed that silibinin induces glioma cell death and its effect was effectively prevented by calpain inhibitor. The present study was therefore undertaken to examine the role of calpain in the silibinin-induced glioma cell death.MethodsU87MG cells were grown on well tissue culture plates and cell… CONTINUE READING

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